Nature Biotechnology - Recording transcriptional histories

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Nature Biotechnology - Recording transcriptional histories
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The May issue is live On our cover, human embryonic kidney cells express a protein-based ticker tape recorder stained with colored dyes. The ticker tape designs from Lin et al. record single-cell transcriptional histories over time

We developed a wireless smart bandage with sensors that can detect the condition of a wound and stimulators that can deliver electric cues. Application of our device on wounds in mouse models reduced infection and accelerated wound healing.

Development is orchestrated in part by myriad chromatin-associated proteins that decorate the genome and physically coordinate in ways that are often unclear. An epigenomics technique called MulTI-Tag maps the genomic locations of different chromatin proteins in the same individual cells, helping to unveil their interactions.

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