Dual sequencing of the epigenome and genome could have broad implications in oncology, write James M. George & ArulChinnaiyan NBTNV
. To be clinically relevant, new sequencing methods should be able to identify epigenetic modifications while preserving the high accuracy of genome sequencing. A study inachieves this goal for the physiologically important epigenetic modifications 5-methylcytosine and 5-hydroxymethylcytosine .
Their six-base sequencing method accurately identifies these two modified bases along with the four unmodified DNA bases in a single workflow. The approach has exciting implications for a wide array of applications including clinical sequencing, as the authors demonstrate in a test liquid biopsy from a patient with colon cancer.
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