Nasal vaccines for COVID-19 offer hope and face hurdles

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Nasal vaccines for COVID-19 offer hope and face hurdles
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A squirt up the nose could reduce coronavirus transmission, but the vaccines have challenges to overcome.

better than the first two shots — especially for older people, studies show . But even with death rates down, that doesn’t mean our fight with coronavirus is over. Waning immune defenses combined with slippery versions of the coronavirus that can evade parts of our immune systems leave vaccinated people susceptible to infection. So we still need additional protection.

A panel of experts advising the U.S. Food and Drug Administration will meet later this month to weigh in on whether we might need a vaccine update for the fall. Updated shots may indeed be on the horizon: Preliminary data from vaccine developer Moderna show that its latest vaccine, which includes both omicron and the original virus,as well as other variants such as delta, the company announced on June 8.

And on June 7 the FDA advisory committee recommended that the agency authorize a new COVID-19 vaccine for emergency use. This one, developed by the company Novavax, — showing the immune system purified viral proteins — which may be appealing to still unvaccinated people who are hesitant about the novel mRNA technology in Moderna’s and Pfizer’s shots . Other experts are working on vaccines that might hold up against an onslaught of variants, both present and future. And then, there are the nasal spray vaccines. They could not only protect our lungs, but also the mucous membranes that line the upper regions of our respiratory tracts such as the nose.

That type of alarm system isn’t a brand-new tool. For example, there is a nasal influenza vaccine available in the United States called FluMist, which teaches the body to recognize four different strains. And there is a similar one in Europe called Fluenz Tetra. Each flu virus included in these vaccines is weakened but can replicate in the body. The attenuated viruses grow best at, not the warm environment of our lungs, a barrier that keeps them from making it to the lungs and causing influenza.

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