An analysis of the two largest US mortality databases found the risk of mortality due to early-onset colorectal cancer most pronounced in those aged 20-44 years.
has increased considerably across the United States over the past two decades, with the effects most pronounced in those aged 20-44 years, according to a new analysis of the two largest US mortality databases.
Abboud and colleagues collected age-adjusted mortality rates for EO-CRC between 2000-2022 from the NCHS database. In addition, stage-specific incidence-based mortality rates between 2004-2020 were obtained from the SEER 22 database. The NCHS database covers approximately 100% of the US population, whereas the SEER 22 database, which is included within the NCHS, covers 42%.
In the cohort aged 45-54 years, mortality decreased between 2000-2005 and increased thereafter, whereas in the cohort aged 20-44 years mortality increased steadily for the entire follow-up duration of 2000 to 2022 . A comparison of the age cohorts confirmed that those aged 20-44 years had a greater increase in mortality . Mortality increased in patients aged 45-54 years with early-stage tumors, but there were insufficient numbers in those aged 20-44 years to determine this outcome.
"I suspect many of younger patients with CRC had their cancer detected when it was more advanced due to delayed presentation and diagnostic testing," said Johnson, who was not involved in the study.
Colorectal Cancer (CRC) Cancer Malignant Neoplasia Carcinoma Malignant Neoplasm Tumor Anemia Anaemia Change In Bowels Chemotherapy Epidemiology Gastrointestinal Hemorrhage Gastrointestinal Bleeding Gi Hemorrhage Gi Bleeding Geriatrics Elder Care Geriatric Medicine Older Adults Seniors Senior Citizens Elderly Neoadjuvant Preventive Screening Screening Young Adult
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