An injectable hydrogel provided a sustained release of semaglutide for 1 month in rats, according to preclinical testing of an experimental longer-acting formulation.
MADRID — In a rat study, two versions of an experimental monthly injectable semaglutide-loaded hydrogel show extended release over 1 month and good tolerance. If found to be safe and effective in people, a once-monthly formulation could improve patient adherence and quality of life of those with type 2 diabetes or obesity.
After injection, the formulations form either a gel disk or microgel suspension that enables a gradual and prolonged drug release. The experimental semaglutide-loaded hydrogel disk or microgel particles were injected subcutaneously in six wild-type Wistar Han male rats of normal weight to characterize semaglutide pharmacokinetics and hydrogel biocompatibility.The formulation could be easily injected using a 25G needle, with gelation starting within minutes of mixing.
Diabetes Mellitus Type Ii Type 2 Diabetes Type 2 DM T2DM T2D GLP-1 Receptor Agonists Glucagon-Like Peptide-1 Receptor Agonists Adherence Adherence To Medication Issues For Patients Compliance Drug Compliance Treatment Adherence Obesity Obese Artificial Intelligence Deep Learning AI NPL Machine Learning ML Natural Language Processing
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