A new analysis reveals how Staphylococcus aureus gains mutations that allow it to colonize eczema patches. Human skin is home to millions of microbes. One of these microbes, Staphylococcus aureus, is an opportunistic pathogen that can invade patches of skin affected by eczema, also known as atopi
In a groundbreaking study, researchers from MIT and other institutions discovered that the microbe Staphylococcus aureus, commonly found on human skin, can rapidly evolve within a person’s microbiome, especially in those with eczema. The microbe evolves into a variant with a mutation in a specific gene, allowing it to grow faster on the skin, making eczema symptoms worse.
Lieberman and Maria Teresa García-Romero, a dermatologist and assistant professor at the National Institute of Pediatrics in Mexico, are the senior authors of the study, which appears on April 12 in the scientific journal. Felix Key, a former MIT postdoc who is now a group leader at the Max Planck Institute for Infection Biology, is the lead author of the paper.in their nostrils, where it is usually harmless.
To answer those questions, the researchers recruited patients aged 5 to 15 who were being treated for moderate to severe eczema. They took samples of the microbes on their skin once a month for three months, and then again at nine months. Samples were taken from the backs of the knees and inside of the elbows , the forearms, which are usually not affected, and the nostrils.
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