Microbe's Diet Unlocked: Insights into Gut Health and Disease

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Microbe's Diet Unlocked: Insights into Gut Health and Disease
MICROBIOMEGUTSMUCUS
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A study reveals the mechanisms behind how a gut microbe, associated with good health, breaks down sugars in mucus. Researchers analyzed 66 enzymes used by the microbe, demonstrating its ability to completely digest mucin from a pig model. This discovery offers new understanding of the link between gut microbes, mucus, and disease.

A microbe found in the lower part of the gut that is associated with good health has been comprehensively analyzed and found to have a focused diet breaking down sugars locked away in mucus, according to a new study.

Using mucus taken from a pig model, the team led by Dr Lucy Crouch from the University of Birmingham found that a combination of enzymes from AM were able to completely break down the mucin. This establishes the first comprehensive understanding of the molecular mechanisms behind how any microbe breaks down the O-linked sugars.

"This is the first time that we have comprehensively seen how microbes break down the food source O-linked sugars in the gut. This is the first time that a set of enzymes has been used to completely break down the glycan part of mucin. These newly characterised enzymes may be used in characterising the different glycans that humans produce, which can be indicative of disease.

A study analyzed data from people aged 40 to 69 and found a causal link between habitual napping and larger total brain volume -- a marker of good brain health linked to a lower risk of dementia and ...

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