Seven mice have been born using cells only from male mice
at Kyushu University in Japan at the Third International Summit on Human Genome Editing in London on 8 March. The symptoms of the condition, known as Turner syndrome, vary widely but almost always include infertility because normal egg development requires two X chromosomes.
Hayashi and his team wanted to see if cells with one X could be turned into cells with two Xs. To do this, it is easiest to start with male cells, which contain one X and one Y, as the Y is the smallest and most dispensable chromosome – and it isThe researchers created stem cells from 8-week-old male mice and picked out ones that spontaneously lost the Y chromosomes.
“The biggest trick of this is the duplication of the X chromosome,” says Hayashi, whose team has previouslyThe researchers used these methods to turn the XX cells into egg cells and used sperm from male mice to fertilise them. Over 600 embryos were then implanted into female mice, resulting in seven apparently healthy pups, said Hayashi.Get the most essential health and fitness news in your inbox every Saturday.
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