A hormone injection that halves the time drunk mice take to sober up could one day be used to treat acute alcohol poisoning in people
In people, drinking alcohol raises the amount of noradrenaline produced by the brain. This may occur via FGF21, which would suggest that administering this might similarly help drunk people to become sober, says Kliewer.
While further research is required, an FGF21 injection could be given to people who arrive in hospital with acute alcohol poisoning. Once conscious and coherent, doctors could then question them and treat them faster. In another part of the experiment, FGF21 had no effect on the ability of mice to recover from being sedated by drugs such as ketamine, which suggests that the hormone’s sobering effect is alcohol specific. “It means that there are specific neurons in that centre of the brain that are likely involved in different responses to different situations,” says Mangelsdorf.
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