Still unknown, however, is whether the effects of magnesium sulfate vary according to patient characteristics.
An updated Cochrane Systematic Review of magnesium sulfate administered before preterm birth for neuroprotection has reaffirmed that the compound significantly reduces the risk of cerebral palsy and has added the finding that it also may reduce the risk of severe neonatal intraventricular hemorrhage.
In the United States, the American College of Obstetricians and Gynecologists advises institutions to develop their own guidelines regarding inclusion criteria and treatment regimens"in accordance with one of the larger trials." , in keeping with the protocols used in thepublished by the National Institute of Child Health and Human Development .
Up to 2 years of corrected age, magnesium sulfate reduced the risk of cerebral palsy compared with placebo and death or cerebral palsy , with a high-certainty grade of evidence. The number needed to treat to prevent one case of cerebral palsy was 60 and the number needed to treat death or cerebral palsy was 56. The impact on severe intracranial hemorrhage , a secondary outcome, was backed by moderate-certainty evidence.
Pregnant Cerebral Palsy Premature Birth Preterm Birth Birth Patient Safety Adverse Effects Side Effects Neuroprotection Intracranial Hemorrhage Intracranial Bleeding Intracranial Haemorrhage Intraventricular Hemorrhage Intraventricular Bleeding Children Child Childhood Pediatrics Kids Hemorrhage Bleeding Maryland Arrhythmia Biologic Therapy Biologics Clinical Guidelines
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