Scientists at the University of Geneva have developed a groundbreaking tool that activates molecules in a specific location within a living organism using a short pulse of light. This precise activation could revolutionize medical treatments by minimizing side effects and enabling targeted therapies.
Acting in the right place at the right time is the key to effective medical treatment with minimal side effects. However, this feat remains difficult to achieve. Biologists and chemists have now succeeded in developing a tool that controls the location at which a molecule is activated by a simple pulse of light lasting only a few seconds.
Tested on a protein essential for cell division, this system could be applied to other molecules. The potential applications are vast, both in basic research and in improving existing medical treatments, such as those for skin cancer. Acting in the right place at the right time is the key to effective medical treatment with minimal side effects. However, this feat remains difficult to achieve. Biologists and chemists at the University of Geneva have succeeded in developing a tool that controls the location at which a molecule is activated by a simple pulse of light lasting only a few seconds. Tested on a protein essential for cell division, this system could be applied to other molecules. The potential applications are vast, both in basic research and in improving existing medical treatments, such as those for skin cancer. These results are published in the journalRegardless of how it is administered, a medication does not only act on the organ affected but has a systemic effect on the entire body. This lack of precision carries risks: it may miss its target and not have the desired effect, or it may cause potentially serious side effects. In Switzerland alone, thousands of people suffer from severe drug-related side effects each year. The solution, simple in theory but highly complex in practice, would be to activate drugs only at the location where they are needed. This challenging research task would however make it possible to activate or inactivate a protein in a living organism at a specific location to better understand its functions. ''Everything started from this methodological question,'' recalls Monica Gotta, Professor in the Department of Cell Physiology and Metabolism at UNIGE Faculty of Medicine, who initiated and coordinated this research with Nicolas Winssinger, Professor in the Department of Organic Chemistry at UNIGE Faculty of Science. ''We were looking for a way to inhibit a protein involved in cell division, the Plk1 protein, when and where we wanted, to better understand its function in the development of an organism''.By combining their expertise in chemistry and biology, the scientists were able to modify a Plk1 inhibitor molecule so that it would be activated by a pulse of light. ''After a complex process, we were able to block the active site of our inhibitor with a coumarin derivative, a compound naturally present in certain plants. This coumarin could then be removed with a simple light pulse,'' explains Victoria von Glasenapp, a postdoctoral researcher in the laboratories of Professor Gotta at the Faculty of Medicine and Professor Winssinger at the Faculty of Science, and first author of the study. The challenge was still to find a way to anchor the inhibitor at the exact point in the body where its action was desired. ''We thus modified the inhibitor so that it becomes trapped in the targeted cell by adding a molecular anchor that is released only by light,'' explains Nicolas Winssinger. ''This enabled us to activate and anchor the inhibitor with the same light pulse, thereby inactivating Plk1 and stopping cell division at the precise desired location.''The system developed by the UNIGE scientists makes it possible to spatially and temporally control the activity of a molecule in a living organism using light. It can be adapted to numerous molecules to be able to activate a drug only where it is needed. In the future, a simple laser could therefore activate a treatment exactly where it is needed while sparing the surrounding healthy tissue, thereby limiting undesirable side effects. ''We hope that our tool will be widely used, leading to a better understanding of how living organisms function and, in the long term, to the development of location-specific treatments,'' concludes Monica Gotta.Chicago Scientists have developed a unique nanolaser. Although the dimensions of this laser are so small that its structure can only be seen through a powerful microscope, its potential is vast. With ... Certain types of light have proven to be an effective, minimally invasive treatment for cancers located on or near the skin when combined with a light-activated drug. But deep-seated cancers have ... Cardiovascular diseases remain a leading cause of death around the world. A primary contributor to these afflictions is high blood pressure, or hypertension. While treatments exist for the condition, ... Cell biologists have found a key clue in the mystery of how chromosomes are inherited correctly every time a cell divides. Using a novel cell probe, they unraveled how a 'matchmaker' molecule stops ...300 New Intermediate-Mass Black Holes Plus 2500 New Active Black Holes in Dwarf Galaxies DiscoveredCoffee Grounds and Reishi Mushroom Spores Can Be 3D Printed Into a Compostable Alternative to Plastics
MEDICAL TREATMENT PRECISION MEDICINE MOLECULAR ACTIVATION LIGHT THERAPY CELL DIVISION
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