A Review published in BMCEndocrDisord highlights the emerging areas of research that could be considered for integration into future classifications of lifestyle management in polycystic ovary syndrome.
Viewing lifestyle modifications through a whole person or holistic care lens. The key features of whole person or holistic care listed in the centre of the figure have been adapted from Thomas et al. []. ‘Recognises individual personhood’ relates to focusing on the unique needs of the person rather than the disease. ‘Importance of therapeutic relationship’ emphasises patient autonomy and responsibility.
A recent Cochrane review of 15 randomised controlled trials and 498 participants, reported that lifestyle interventions compared with minimal intervention or usual care, significantly reduces weight and body mass index and improves secondary reproductive outcomes such as free androgen index , testosterone , sex hormone-binding globulin and hirsutism [
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Multi-omics microsampling for the profiling of lifestyle-associated changes in health - Nature Biomedical EngineeringDense multi-omics microsampling for the frequent capture and analysis of thousands of molecules in blood alongside physiological information from wearables facilitates the profiling of lifestyle-associated changes in an individual’s health.
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Cassette & Co Offers Stylish Lifestyle Apparel for the BicyclistCassette & Co. is part of Cassette Creative, a company that helps create, and manage brand assets and marketing for businesses in the bike industry.
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Polypharmacy during pregnancy and associated risk factors: a retrospective analysis of 577 medication exposures among 1.5 million pregnancies in the UK, 2000-2019 - BMC MedicineBackground The number of medications prescribed during pregnancy has increased over the past few decades. Few studies have described the prevalence of multiple medication use among pregnant women. This study aims to describe the overall prevalence over the last two decades among all pregnant women and those with multimorbidity and to identify risk factors for polypharmacy in pregnancy. Methods A retrospective cohort study was conducted between 2000 and 2019 using the Clinical Practice Research Datalink (CPRD) pregnancy register. Prescription records for 577 medication categories were obtained. Prevalence estimates for polypharmacy (ranging from 2+ to 11+ medications) were presented along with the medications commonly prescribed individually and in pairs during the first trimester and the entire pregnancy period. Logistic regression models were performed to identify risk factors for polypharmacy. Results During the first trimester (812,354 pregnancies), the prevalence of polypharmacy ranged from 24.6% (2+ medications) to 0.1% (11+ medications). During the entire pregnancy period (774,247 pregnancies), the prevalence ranged from 58.7 to 1.4%. Broad-spectrum penicillin (6.6%), compound analgesics (4.5%) and treatment of candidiasis (4.3%) were commonly prescribed. Pairs of medication prescribed to manage different long-term conditions commonly included selective beta 2 agonists or selective serotonin re-uptake inhibitors (SSRIs). Risk factors for being prescribed 2+ medications during the first trimester of pregnancy include being overweight or obese [aOR: 1.16 (1.14–1.18) and 1.55 (1.53–1.57)], belonging to an ethnic minority group [aOR: 2.40 (2.33–2.47), 1.71 (1.65–1.76), 1.41 (1.35–1.47) and 1.39 (1.30–1.49) among women from South Asian, Black, other and mixed ethnicities compared to white women] and smoking or previously smoking [aOR: 1.19 (1.18–1.20) and 1.05 (1.03–1.06)]. Higher and lower age, higher gravidity, increasing number of comorbidities and increasing le
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Cortical Grey matter volume depletion links to neurological sequelae in post COVID-19 “long haulers” - BMC NeurologyObjective COVID-19 (SARS-CoV-2) has been associated with neurological sequelae even in those patients with mild respiratory symptoms. Patients experiencing cognitive symptoms such as “brain fog” and other neurologic sequelae for 8 or more weeks define “long haulers”. There is limited information regarding damage to grey matter (GM) structures occurring in COVID-19 “long haulers”. Advanced imaging techniques can quantify brain volume depletions related to COVID-19 infection which is important as conventional Brain MRI often fails to identify disease correlates. 3-dimensional voxel-based morphometry (3D VBM) analyzes, segments and quantifies key brain volumes allowing comparisons between COVID-19 “long haulers” and normative data drawn from healthy controls, with values based on percentages of intracranial volume. Methods This is a retrospective single center study which analyzed 24 consecutive COVID-19 infected patients with long term neurologic symptoms. Each patient underwent Brain MRI with 3D VBM at median time of 85 days following laboratory confirmation. All patients had relatively mild respiratory symptoms not requiring oxygen supplementation, hospitalization, or assisted ventilation. 3D VBM was obtained for whole brain and forebrain parenchyma, cortical grey matter (CGM), hippocampus, and thalamus. Results The results demonstrate a statistically significant depletion of CGM volume in 24 COVID-19 infected patients. Reduced CGM volume likely influences their long term neurological sequelae and may impair post COVID-19 patient’s quality of life and productivity. Conclusion This study contributes to understanding effects of COVID-19 infection on patient’s neurocognitive and neurological function, with potential for producing serious long term personal and economic consequences, and ongoing challenges to public health systems.
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The relationship between fatigue, sleep quality, resilience, and the risk of postpartum depression: an emphasis on maternal mental health - BMC PsychologyBackground Several factors can contribute to the development of postpartum depression (PPD) and negatively affect mothers’ mental and physical well-being. The objective of this study was to determine the relationship between fatigue, sleep quality, resilience, and the risk of PPD development. Methods A cross-sectional study was conducted using an online questionnaire distributed to mothers during their postpartum period. The risk of PPD was assessed using the Edinburgh Postnatal Depression Scale (EPDS), postpartum fatigue (PPF) was assessed using the Fatigue Severity Scale (FSS), sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI), and resilience was assessed using the Brief Resilience Scale (BRS). The Pearson correlation coefficient was calculated to determine the relationship between the study variables. Simple and multiple linear regression analyses were performed to explain the contributions of PPF, sleep quality, and resilience as independent predictors of PPD development. Results A total of 1409 postpartum women were included in the analysis, with 75% of the participants reporting a risk of PPD, 61% reporting PPF, 97% reporting having sleep problems, and 36% being in the “low resilience level” category. In terms of correlations, the scores of FSS and the PSQI showed moderate positive relationships with the EPDS scores (r = 0.344 and r = 0.447, respectively, p = .000). The BRS scores were negatively associated with the EPDS scores (r = −0.530, p = 0.000). Fatigue, sleep quality, and resilience were predictors of depressive symptoms (β = 0.127, β = 0.262, and β = −0.393, respectively, R2 = 0.37, p = 0.000). The association remained significant in the regression model after adjusting for mother’s age, mother’s BMI, child’s age, smoking status, full-term pregnancy, having a chronic disease, and taking anti-depressant. Conclusions Mothers with higher levels of fatigue, poor sleep quality, and low resilience levels were at high risk of develop
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Too fast to catch?: a perspective on the state of transposable elements in research - BMC Series blogWe would like to attract your attention to our new BMC Genomics collection, titled 'Transposable elements'. More information can be found in this blog post written by Guest Editor Gökhan Karakülah and his PhD student Doğa Eskier who discuss the importance of transposable elements (TEs) and shine a spotlight on our current and growing knowledge of TEs.
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