A geneticist studied one drop of his blood—and saw things he couldn't from a vial of blood natBME
. However, for DBS, the haematocrit effect affects the resulting spot size, which can introduce variation in analysis. As the microsampling approach is less invasive and can be used remotely and without specific training, it enables high-frequency blood sample collection in a native setting, which is difficult to perform using the classic blood sampling approach.
It is worth noting that most analytes that we measure, particularly proteins, appear stable with regard to time, temperature and the combination of both.
In summary, the presented methodology achieves fully remote, scalable, high-temporal-resolution omics and sensor monitoring. It has the potential for large-scale comprehensive, dynamic molecular and digital biomarker discovery and monitoring as well as health profiling. Here we used two case studies to show the potential of multi-omics microsampling in precision medicine. Many other applications can be envisioned. Examples include: Longitudinal biomarker discovery.
The two pilot case studies were used to demonstrate the power and application of the approach. The molecular signatures found in our study provide vast testable hypotheses that should be validated using analytical and experimental approaches. We note that group analysis is usually performed to find the overall trend. However, it can be potentially used to identify individual outliers who may have underlying conditions.
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