The largest-ever study of the genetics of the brain which analyzed around 36,000 brain scans, has pinpointed over 4,000 genetic factors associated with brain structure. The research, led by the University of Cambridge team, was recently published in the journal Nature Genetics. Our brains are int
The largest-ever study of brain genetics has identified over 4,000 genetic variants associated with brain structure.
, accessed MRI scans from over 32,000 adults from the UK Biobank cohort and over 4,000 children from the US-based ABCD study. From these scans, the researchers measured multiple properties of the outermost layer of the brain called the cortex. These included measures of the area and volume of the cortex as well as how the cortex is folded.
These findings have allowed researchers to confirm and, in some cases, identify, how different properties of the brain are genetically linked to each other. The team also checked whether the same genes that are linked to variation in brain size in the general population overlap with genes linked to clinical conditions where head sizes are much larger or smaller than the general population, known as cephalic conditions.
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