IMTOZ trial findings and subsequent approval of Isa-VRd regimen for transplant-ineligible myeloma suggested the combo as a new frontline standard of care.
reduced the risk for disease progression or death by more than 40% vs VRd alone in the randomized, global, open-label, phase 3 IMROZ trial., support the four-drug combination known as Isa-VRd as a potential new standard of care supplanting VRd alone as the SOC in this setting, according to Meletios Dimopoulos, MD, of the University of Athens, Athens, Greece.
However, both noted that despite having a favorable safety profile similar to VRd, Isa-VRd may not be well tolerated in elderly and frail patients. Demonstrably frail patients were excluded from IMROZ, and this is a factor that should be considered in the practice setting, they agreed."The cutoff for transplant eligibility differs from one country to another, and today, we do not have consensus around an agreed-upon age limit," Beksac said.
"In many centers in Europe, these patients would be considered transplant eligible. Hence, for this group of patients who are not too old, but not too young, and fit, IMROZ is offering a non-transplant-based treatment with similar efficacy to what can be achieved with HSCT," Mohty added.
For example, the quadruplet may be combined"in a kind of VRd-light version to start with, and maybe we can adapt later depending on the tolerability of the patient," Beksac added.
Myeloma Plasma Cell Myeloma Transplantation Transplant Transplantation Of Stem Cells Transplantation Of Hematopoietic Stem Cells Hematopoietic Stem Cell Transplant Stem Cell Transplantation Stem Cell Therapy Stem Cell Haematopoietic Stem Cell Transplant HSCT Hematopoietic Stem Cell Transplantation (HSCT) Haematopoietic Stem Cell Transplantation (HSCT)
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