Investigators assess the impact of increasing persistent PSA levels on prostate cancer–specific mortality and all-cause mortality risk.
Higher persistent PSA levels post-surgery were linked to increased mortality risk, with 8-year prostate cancer –specific mortality reaching 13.86% for a prostate-specific antigen ≥ 1 ng/mL.The conventional 1.
5-month to 2.0-month time interval following radical prostatectomy for assessing persistent PSA remained questionable for accuracy. Analysis included 43,298 patients with clinical stage T1N0M0 to T3N0M0 prostate cancer treated with RP between 1992 and 2020 at two academic centers, with follow-up data collected until November 2023. Researchers evaluated whether a significant interaction existed between pre-RP PSA level and persistent vs undetectable PSA after RP on mortality risk, adjusting for known prognostic factors. Investigators assessed the impact of increasing persistent PSA levels on prostate cancer–specific mortality and all-cause mortality risk, with a median follow-up of 6.23 years. Patients with PSA >20 ng/mL or Gleason score 8-10 underwent CT or MRI and bone scan prior to surgery.Among patients with persistent PSA, those with pre-RP PSA >20 ng/mL showed significantly reduced all-cause mortality risk for persistent PSA ≥ 1 ng/mL vs 8.17% for 20 ng/mL vs ≤ 20 ng/mL. This limitation may be explained by the limited power to assess the all-cause mortality endpoint given the shorter median follow-up and smaller event rate in the validation cohort compared with the discovery cohort.Tilki reported receiving personal fees from Amgen, Apogepha, AstraZeneca, Astellas, A3P Biomedical, Bayer, Exact Sciences, Johnson & Johnson, Ipsen, Novartis, Pfizer, Roche, Veracyte, and Takeda outside the submitted work. No other disclosures were reported. This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.
Malignant Prostate Neoplasm Prostate Cancer Cancer Of The Prostate Prostatic Cancer Malignant Neoplasia Carcinoma Malignant Neoplasm Prostate Specific Antigen Prostate Specific Antigen (PSA) Biologic Therapy Biologics Surgery Bone Scan Bone Imaging Computed Tomography CT Ct Scan Radical Prostatectomy Antigens Artificial Intelligence Deep Learning AI NPL
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