Disease-modifying antirheumatic drugs can reduce some cardiovascular risk in patients with rheumatoid arthritis, but questions remain if that's enough when statin use lags.
NEW YORK — Patients with rheumatoid arthritis carry a high risk for cardiovascular events, but mounting clinical evidence suggests they're being undertreated to manage that risk. Rheumatologists should consider a patient with RA's cardiovascular disease status before deciding on RA treatments, a researcher of cardiometabolic disorders advised.
Those results were driven entirely by low serum amyloid A levels, Giles said. Those same results didn't hold for patients in whom SAA and C-reactive protein were correlated.Nonetheless, he said, sufficient evidence exists to conclude that treating RA to target reduces CV events.
Giles'"gut feeling" on JAK inhibitors is that they're not causing harm, but that they're not as effective as TNF inhibitors in ameliorating CV risks in patients with RA. Garshick said he's specifically interested in the residual risk that exists after treating the autoimmunity."Do you still have a higher risk for heart disease, and if so, why? Is there something else going on that we can't see?"
RA - Rheumatoid Arthritis Rheumatoid Arthritis (RA) CV Risk Cardiovascular Risk CV Risk Factors Cardiovascular Risk Factors Cardiovascular Risk Management Jak/Stat Jak-Stat Signaling Pathway Jak-Stat Cytokine Receptors Anti-Tnf Anti-Tumor Necrosis Factor Anti-Tumour Necrosis Factor Atherosclerotic Heart Disease Atherosclerotic Cardiovascular Disease
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