Improving prostate cancer screening: accounting for genetic determinants of PSA variation NatureMedicine UofCalifornia prostate prostatecancer genetics geneticdeterminants PSA
By Dr. Chinta SidharthanJun 5 2023Reviewed by Lily Ramsey, LLM In a recent study published in Nature Medicine, researchers conducted a genome-wide analysis of prostate-specific antigen levels of men without prostate cancer to understand the non-cancer-related variation in PSA levels to improve decision-making during the diagnosis of prostate cancer.
Other factors, such as an inflammation or infection of the prostate gland, age, and benign prostatic hyperplasia, can also increase the levels of PSA in circulation. Furthermore, while low PSA levels are generally associated with being overweight or obese, it cannot eliminate the possibility of prostate cancer.
About the study In the present study, the researchers used data from five previous studies that included men without prostate cancer diagnoses to conduct a genome-wide analysis of PSA levels. The results from the genome-wide analyses were then meta-analyzed across different ancestries and populations.
Furthermore, the analyses were limited to a PSA level range of greater than 0.01 ng per ml and less than or equal to 10 ng per ml, corresponding to functional prostate and low-risk prostate cancer, respectively, to reduce potential reverse causation. The results of the meta-analyses, stratified according to ancestry, were then used to develop a genome-wide polygenic score for PSA, which was then validated using the Prostate Cancer Prevention Trial and the Selenium and Vitamin E Cancer Prevention Trial cohorts.
Furthermore, using PSAG would result in a 31% reduction in negative biopsies among men of European ancestry and reduce the need for biopsies in prostate cancer patients by 12%.
United States Latest News, United States Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Cyclists wearing helmets seen as 'less human' than those without, researchers find'Our findings add to this growing research, suggesting that cyclists wearing safety attire, particularly high-visibility vests, may be dehumanised more so than cyclists without safety attire'
Read more »
Older children under-five living in low incomes large families in rural areas are most vulnerable to malaria infectionOlder children under-five living in low incomes large families in rural areas are most vulnerable to malaria infection PLOSONE rural LMICs LMIC vulnerable malaria infection
Read more »
Quantifying the impact of intermittent fasting on appetiteQuantifying the impact of intermittent fasting on appetite Nutrients_MDPI BristolUni intermittentfasting fasting IF diet appetite nutrients
Read more »
Is translocator protein distribution volume elevated in the brain after acute COVID-19 infection with sequelae of depressive and cognitive symptoms?Is translocator protein distribution volume elevated in the brain after acute COVID-19 infection with sequelae of depressive and cognitive symptoms? JAMAPsych translocator protein distribution brain covid COVID19 SARSCoV2
Read more »
An overview of the French antibiotic resistance surveillance system in the human, animal, and environmental sectorsAn overview of the French antibiotic resistance surveillance system in the human, animal, and environmental sectors Eurosurveillanc antibioticresistace ABR AMR human animal environmental sectors
Read more »
Flavanol consumption improves hippocampal memory function associated with cognitive agingFlavanol consumption improves hippocampal memory function associated with cognitive aging PNASNews Columbia flavanol hippocampal memory function cognative aging
Read more »