The findings add to a growing body of literature supporting the relative safety of immunosuppressive therapy to treat IBD in patients who have a history of cancer.
In patients with inflammatory bowel disease and a history of cancer, immunosuppressive therapies don't appear to increase the risk for incident cancer, according to an interim analysis of the SAPPHIRE registry.
In the interim analysis, Itzkowitz and colleagues looked at the development of incident cancer . The researchers excluded patients receiving active cancer treatment or who had more than one cancer before enrollment. Index cancers were solid organ , dermatologic , gastrointestinal , and hematologic . Of index cancers with known stage information, 33% were stage I.
In an unadjusted analysis, the crude rate of incident cancer in unexposed patients was 2.58 per 100 person-years vs 4.78 per 100 person-years among patients exposed to immunosuppression . SAPPHIRE researchers plan to continue to follow the existing patients and enroll new patients, particularly as new IBD medications are introduced into clinical practice, Itzkowitz said. The research team is also considering studies that investigate patients with IBD who are undergoing active cancer treatment.
IBD - Inflammatory Bowel Disease IBD Cancer Malignant Neoplasia Carcinoma Malignant Neoplasm Cancer Risk Biologic Therapy Biologics Nonmelanoma Skin Cancer Skin Cancer Malignant Skin Neoplasm Colorectal Cancer Colorectal Cancer (CRC) Immunosuppressive Therapy Immunosuppressive Agents Immunosuppressive Drugs Immunocompromise Immunocompromised
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