A large randomized trial found no difference in oncology outcomes or reconstruction complications with accelerated radiation regimens after mastectomy.
Over the past decade, radiation oncologists have moved toward hypofractionated regimens for breast cancer to ease the burden of treatment. The benefit of shorter radiation treatment durations at higher doses is less time in the clinic and lower out-of-pocket costs for patients. For those who live far away, this time- and cost-saving approach could make the difference between having radiation or forgoing it.
"Now we have robust data from hundreds of academic and community centers and from patients with any type of reconstruction that clearly show the safety and effectiveness of short course radiation," principal investigator."The results of this trial show we can safely reduce treatment time for these patients to 3 weeks, without compromising their reconstruction."
Women in the trial had unilateral invasive pT0-2, pN1-2, or pT3N0 breast cancer. Patients received treatment at 209 centers across the US and Canada, and they were a median of 46 years of age. The total radiation dose was 50 Gy in the conventional regimen arm and 42.56 Gy in the hypofractionated regimen arm.
Malignant Breast Neoplasm Breast Carcinoma Aesthetic Medicine Facial Rejuvenation Breast Reconstruction Breast Prosthesis Reconstruction Of The Breast Breast Mammary Gland Mastectomy Wound Management Wound Care Cancer Malignant Neoplasia Carcinoma Malignant Neoplasm Radiation Therapy Radiotherapy Radiation Oncology Wound Healing Wound Repair Radiation Dose Wound
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