Patients were randomized to receive either hypofractionated radiotherapy or conventional fractionation.
Rivera, who is an oncologist and radiotherapist, said these findings could change clinical practice, potentially making 3-week radiotherapy regimens a new standard for patients requiring nodal irradiation.Hypofractionated radiotherapy, which delivers larger doses per fraction over a shorter overall treatment time, has become the standard practice for whole breast irradiation in many countries, said Rivera, who is the head of the Radiotherapy Department of Gustave Roussy, Villejuif, France.
This open-label, multicenter, randomized, phase 3 trial enrolled 1265 patients across 29 centers in France between September 2016 and March 2020. Eligible patients were 18 years or older with T1-3, N0-3, M0 breast cancer requiring nodal irradiation. "Cardiac disorders at 5 years were really limited," Rivera noted,"and the most frequent side effects were, of course, fatigue, fibrosis, pain, and radiation skin injury with something very balanced between the two arms.
She also placed the findings from the HypoG-01 trial into the broader context of evolving breast radiotherapy practices.
Malignant Breast Neoplasm Breast Carcinoma Radiation Therapy Radiotherapy Radiation Oncology Toxicology Toxicity Poisoning Toxins Physical Medicine And Rehabilitation Physiatry PM&R Local-Regional Breast Cancer Locoregional Breast Cancer Breast Mammary Gland Lymphedema Lymphoedema Lymphatic Obstruction Cancer Malignant Neoplasia Carcinoma Malignant Neoplasm
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