Study shows more mutations likely with genetically engineered syntheticDNA uniofsurrey
ing in base mismatch under replication. First, we present a proton transfer mechanism for hachimoji DNA, analogous to the one presented by Löwdin years prior. Then, we use density functional theory to calculate proton transfer rates, tunnelling factors and the kinetic isotope effect in hachimoji DNA.
We determined that the reaction barriers are sufficiently low that proton transfer is likely to occur even at biological temperatures. Furthermore, the rates of proton transfer of hachimoji DNA are much faster than in Watson–Crick DNA due to the barrier for Z–P and S–B being 30% lower than in G–C and A–T. Suggesting that proton transfer occurs more frequently in hachimoji DNA than canonical DNA, potentially leading to a higher mutation rate.
United States Latest News, United States Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
UFOs will remain mysterious without better data, NASA study team says'This work is in our DNA.'
Read more »
Study examines how DNA damage is repaired by antioxidant enzymesA typical human cell is metabolically active, roaring with chemical reactions that convert nutrients into energy and useful products that sustain life. These reactions also create reactive oxygen species, dangerous by-products like hydrogen peroxide which damage the building blocks of DNA in the same way oxygen and water corrode metal and form rust. Similar to how buildings collapse from the cumulative effect of rust, reactive oxygen species threaten a genome's integrity.
Read more »
Suspected Serial Rapist Arrested in NJ After DNA Tech Tied Him to Years-Old CrimesA suspected serial rapist tied to a series of sexual assaults and kidnappings in a Boston neighborhood more than a decade ago was arrested in New Jersey, police said, after investigators tied him to the crimes using DNA technology and a public database.
Read more »
Sucralose Damages DNA, Linked to Leaky Gut: Study‼️ A new study reveals health concerns about the sugar substitute sucralose so alarming that researchers said people should stop eating it and the government should regulate it more.
Read more »
NYC cyber attorney Matthew Nilo charged in connection with 3 Boston rapesNilo was identified to law enforcement through family members who voluntarily sent DNA samples to a genealogy database, like '23 and Me.'
Read more »