Study examines how DNAdamage is repaired by antioxidantenzymes
at their source before they reach DNA, a defensive strategy that protects the roughly 3 billion nucleotides from suffering potentially catastrophic mutations. If DNA damage occurs anyway, cells pause momentarily and carry out repairs, synthesizing new building blocks and filling in the gaps.in maintaining genome integrity, there has been no systematic, unbiased study on how metabolic perturbations affect the DNA damage and repair process.
The findings represent a paradigm shift in cellular biology because it suggests the nucleus is metabolically active."Where there's smoke there's fire, and where there's reactive oxygen species there are metabolic enzymes at work. Historically, we've thought of the nucleus as a metabolically inert organelle that imports all its needs from the cytoplasm, but our study demonstrates that another type of metabolism exists in cells and is found in the nucleus," says Dr.
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