How Gene Editing Therapies Could Go Beyond Rare Diseases

CRISPR News

How Gene Editing Therapies Could Go Beyond Rare Diseases
HIVExcision BiotherapeuticsGene Editing
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I am a medical doctor and venture investor in healthcare, biotech, and agriculture with more than 20 years of experience.

photo. Born in Nigeria, he is very interested in Casgevy , the CRISPR -based sickle cell treatment that was recently approved by the FDA. He has had both his knees, shoulders and hips replaced because of SCD. HIV from immune cells in the lab, an eye-catching approach that is forming the basis of potentially curative therapies for the disease.around the world and while it is no longer a death sentence thanks to antiretroviral drugs, there is still no recognized cure.

One day, she believes, CRISPR could offer a new way of targeting a range of chronic viral infections, not just HIV. “With its precise gene-editing capabilities, CRISPR can potential target and disrupt viral genomes, both DNA and RNA, offering new avenues for the treatment and prevention of infectious diseases,” she says. “It has been utilized to target the SARS-CoV-2 genome, and it could be employed to combat hepatitis B.

“We’re working on developing safer and smaller Cas nucleases that would be more compatible with diverse delivery technologies,” says Monika Paule, CEO of Caszyme. “Because there are so many different variants, a monumental number of therapies would be required to treat all patients that suffer from that disease using current gene editing technologies,” he says. “But with a CAST system, you might be able to go in and address all underlying mutations with a single treatment by replacing the same chunk of problematic DNA in every patient.

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HIV Excision Biotherapeutics Gene Editing Gene Editing Therapy ALS Cystic Fibrosis Sickle Cell Casgevy Metagenomi

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