In an effort to improve delivery of costly medical treatments, a team of researchers in electrical engineering has developed a stimulating method that could make the human body more receptive to certain gene therapies.
In an effort to improve delivery of costly medical treatments, a team of researchers in electrical engineering at the University of Wisconsin-Madison has developed a stimulating method that could make the human body more receptive to certain gene therapies.
The project began almost a decade ago with Hans Sollinger, a transplant surgeon at UW-Madison. He had developed a gene therapy treatment for Type 1 diabetes, an autoimmune disease that attacks the pancreas, the organ that produces insulin. "What we started talking about was local, targeted delivery and whether there was a way of getting the treatment DNA directly into the liver without passing it through the entire body and triggering the immune system," says Hagness."And whether we could use electric pulses in order to make this delivery process more efficient and dramatically reduce the dose needed."
When she examined the results 48 hours later under a fluorescence microscope, Yao found that only a small percentage of the cells that hadreceived a zap accumulated about 40 times the amount of the fluorescent green proteins delivered by the virus. Sollinger passed away in May 2023, but the team says his legacy will live on through the ongoing research on this project and the work of other groups. The electrical engineering researchers are pursuing next steps with external funding and are optimistic that ultimately the technique will translate into clinical trials.
Stem Cells Gene Therapy Lymphoma Liver Disease Medical Topics Diabetes Personalized Medicine
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