DNA level changes can hasten aging by roughly five years, according to a UCLA-led study. According to experts at the University of California, Los Angeles, HIV has a 'early and substantial' influence on aging in infected patients, accelerating biological changes in the body associated with normal a
HIV-infected people showed significant age acceleration in four epigenetic “clock” measurements, ranging from 1.9 to 4.8 years, an acceleration that was not seen in non-infected people. Credit: National Institute of Allergy and Infectious Diseases According to experts at theHIV has a “early and substantial” influence on aging in infected patients, accelerating biological changes in the body associated with normal aging within two to three years of infection.
The researchers examined blood samples from 102 males taken six months or less before they got infected with HIV and again two to three years later. They compared them to samples collected during the same time period from 102 non-infected males of the same age. According to the authors, this is the first research to compare infected and non-infected patients in this manner. All of the men were part of the Multicenter AIDS Cohort Study, a countrywide study that began in 1984.
HIV-infected individuals showed significant age acceleration in each of the four epigenetic clock measurements — ranging from 1.9 to 4.8 years — as well as telomere shortening over the period beginning just before infection and ending two to three years after, in the absence of highly active antiretroviral treatment. Similar age acceleration was not seen in the non-infected participants over the same time interval.
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