High prevalence of fungal secondary infections among COVID-19 patients Coronavirus Disease COVID Antifungal Aspergillosis Candida Candidiasis FungalInfection PLOSONE
By Dr. Priyom Bose, Ph.D.Aug 2 2022Reviewed by Benedette Cuffari, M.Sc. The coronavirus disease 2019 pandemic was caused by the emergence of the severe acute respiratory syndrome coronavirus 2 .
Background Related StoriesSome commonly reported secondary fungal infections that are associated with an increased rate of mortality and morbidity include COVID-19-associated pulmonary aspergillosis , mucormycosis , and invasive candidiasis. These infections are caused by pathogens belonging to Rhizopus, Aspergillus, and Candida species, respectively.
The time interval between COVID-19 diagnosis and the development of secondary fungal infections varies significantly among patients. As fungal co-infections increase the risk of mortality in COVID-19 patients, early detection and treatment are important to reduce adverse clinical outcomes. In the current study, the researchers performed a comprehensive literature search using several search engines, including Scopus, PubMed, Cochrane Library, Web of Sciences, ClinicalTrial.gov, medRxiv.org, Google scholar, and bioRxiv.org to obtain relevant studies related to AFTs for secondary fungal infection management in COVID-19 patients.
The mortality rate associated with CAPA and CAM was 75.2% and 13%, respectively. Comparatively, another study reported that the mortality rate associated with CAPA is lower than CAM.An Atlanta-based study reported 30.9% mortality in COVID-19 patients with secondary fungal infections. Several other studies have similarly indicated that as compared to those infected with SARS-CoV-2 alone, COVID-19 patients co-infected with fungal infections have a higher mortality rate.
CAC mostly prevailed among the Chinese population, with these patients predominantly treated with echinocandins, azoles, and amphotericin B. Candida albicans was found to be the causal organism of CAC, with the duration of antifungal treatment ranging from four to 21 days.
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