A new study found that a 162 mg daily dose of aspirin did not offer any significant benefits for preventing preeclampsia compared to a 81 mg dose in pregnant women at risk. Researchers suggest that while more aspirin may not be better, 162 mg could be beneficial for women carrying multiples. Further research is needed to confirm this.
A 162-mg prophylactic daily dose of aspirin did not result in any significant difference in preeclampsia outcomes compared with a daily dose of 81 mg in pregnant women at risk for preeclampsia, according to a trial presented at the
“Our trial suggests that more aspirin may not necessarily be better for preeclampsia prevention in a high-risk population, with a potential for increased adverse events such as bleeding during pregnancy,” Amrin Khander, MD, an assistant professor of OB/GYN at Weill Cornell Medicine, New York City, told. “It is reassuring that for those who do elect to take 162 mg, the overall maternal and neonatal outcomes are the same.
Though low-dose aspirin is known as the only prophylaxis for preeclampsia — reducing risk by up to 60% — it’s less clear what the optimal dose is. Because the only readily available dose available to US consumers is 81 mg, Khander and colleagues tested the protective effects of 81 mg or double that, 162 mg.
The researchers conducted a prospective randomized open-label pragmatic trial at the New York Presbyterian-Weill Cornell Manhattan and Queens campuses from January 2020 to August 2023. The primary outcome, incidence of preterm preeclampsia ( 100 mg is more protective against preeclampsia, Khander raised the question of whether their population was high risk enough.
Though this real-world study was relatively large and diverse, with high adherence, limitations included the open-label design, little geographic diversity, and a high proportion of commercially insured patients.All material on this website is protected by copyright, Copyright © 1994-2025 by WebMD LLC. This website also contains material copyrighted by 3rd parties.
Preeclampsia Aspirin Pregnancy Dosage Outcomes
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