A new study suggests a connection between the human cytomegalovirus (HCMV), the immune response triggered by CD83 antibodies, and Alzheimer's disease (AD). Researchers found that individuals with AD had elevated levels of HCMV and IgG4 in their tissues, particularly in the brain and gut.
Researchers are gaining new insight into the relationship between the human cytomegalovirus (HCMV), a common herpes virus found in the gut, and the immune response associated with CD83 antibody in some individuals with Alzheimer’s disease (AD).
Using tissue samples from deceased donors with AD, the study showed CD83-positive (CD83+) microglia in the superior frontal gyrus (SFG) are significantly associated with elevated immunoglobulin gamma 4 (IgG4) and HCMV in the transverse colon (TC), increased anti-HCMV IgG4 in the cerebrospinal fluid (CSF), and both HCMV and IgG4 in the SFG and vagus nerve. Our results indicate a complex, cross-tissue interaction between HCMV and the host adaptive immune response associated with CD83+ microglia in persons with AD,” the investigators including Benjamin P. Readhead, MBBS, research associate professor, ASU-Banner Neurodegenerative Disease Research Center, Arizona State University, Tempe, Arizona, noted. The results suggest antiviral therapy in patients with biomarker evidence of HCMV, IgG4, or CD83+ microglia might ward off dementia. “We’re preparing to conduct a clinical trial to evaluate whether careful use of existing antivirals might be clinically helpful in preventing or slowing progression of CD83+ associated Alzheimer’s disease,” Readhead toldCMV is a common virus. In the United States, nearly 1 in 3 children are already infected with CMV by age 5 years. Over half the adults have been infected with CMV by age 40 years. It is typically passed through bodily fluids and spread only when the virus is active. It’s not considered a sexually transmitted disease. Compared with other IgG subclasses, IgG4 is believed to be a less inflammatory, and therefore less damaging, immune response. But this response may be less effective at clearing infections and allow invasion of HCMV into the brain. Experts speculate HCMV may travel via the vagus nerve from the colon to the brain where it triggers the onset of A
ALZHEIMER's DISEASE HUMAN CYTOMEGALOVIRUS IMMUNE RESPONSE CD83 ANTIBODY ANTIVIRAL THERAPY
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