Disturbances in the gut may help explain why some patients with schizophrenia are aggressive whereas others are not, new research suggests. MedTwitter
PrevotellaIn the patients who had schizophrenia with aggression, levels of six SCFAs and six neurotransmitters were much lower than in the patients with schizophrenia but no aggression .
The findings"collectively suggest the co-contributory role of systemic pro-inflammation and pro-oxidation in the development of aggression" in schizophrenia, they add."Gut dysbacteriosis with leaky gut seems to play a vital role in the pathophysiology.", Emeran Mayer, MD, distinguished research professor of medicine at the G.
The study's shortcomings include its small sample size as well as several confounding factors — particularly diet, sleep, exercise, and stress and anxiety levels — that were not considered, he said. The study also lacked a control group with high levels of aggression but without schizophrenia. The differences in gut microbial composition and SCFA production"could be secondary to differences in plant-based diet components," Mayer speculated, wondering how well dietary intake was controlled.
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