Outcomes in methotrexate-induced kidney injury have shown improvement through treatment with the enzyme glucarpidase.
is linked to 2.7 times higher odds of kidney recovery and faster recovery time. The enzyme also reduces the risk for grade ≥ 2Researchers conducted a multicenter cohort study involving 708 adults with methotrexate-associated acute kidney injury from 28 cancer centers across the United States.
Analysis utilized a sequential target trial emulation framework to compare outcomes between 209 patients who received glucarpidase within 4 days of methotrexate initiation and 499 patients who did not.Glucarpidase administration was associated with adjusted odds ratio of 2.70 and adjusted hazard ratio of 1.88 for time-to-kidney recovery.
Treatment with glucarpidase reduced the risk for grade ≥ 2 neutropenia and grade ≥ 2 transaminitis on day 7.“These data suggest glucarpidase may improve both renal and extrarenal outcomes in patients with MTX-AKI ,” the authors of the study wrote.This study was led by Shruti Gupta, MD, MPH, and David E. Leaf, MD, MMSc, Brigham and Women’s Hospital in Boston. It wasAccording to the authors, residual confounding cannot be excluded despite adjustment for multiple variables.
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Acute Leukaemia Acute Kidney Injury AKI Acute Renal Failure Acute Kidney Failure Renal Trauma Renal Injury Kidney Trauma Renal Failure Renal Insufficiency Kidney Insufficiency Kidney Failure Renal Impairment Diffuse Large Cell Lymphoma Diffuse Large B-Cell Lymphoma Follicular Lymphoma Mantle Cell Lymphoma Kidneys Hemodialysis Vascular Access Kidney Dialysis
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