Researchers have found definitive proof of a kidney microbiome that influences renal health and kidney stone formation, demonstrating that the urinary tract is not sterile and low levels of bacteria are normal.
Low levels of bacteria like E. coli and Lactobacillus in our urine come from communities in our kidneys, where they promote or prevent kidney stone formation The publication describes the rigorous multi-pronged approach a team used to identify and characterize the small bacterial community by combining preclinical, human and dish studies.
Dr. Miller hopes his team's findings will help overturn the concept of a sterile urinary tract and lead to better prevention or treatment options for a condition that hasn't seen major medical advances in over three decades. First author and urologist José Agudelo, MD, who has extensive experience in urinary stone disease, explains that previous indirect findings of a kidney microbiome gave compelling evidence but left room for doubt.
Dr. Agudelo says his team's findings suggest that different bacteria produce pro- and anti- kidney stone molecules, which he wants to use in new therapeutic and diagnostic techniques. He is already working to understand which bacterial metabolites influence stone formation, and how.
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