The HLA-DRB1*01:03 allele was significantly associated with increased severity of ulcerative colitis, including higher rates of hospitalization, surgery, and corticosteroid use.
who carry the HLA-DRB1*01:03 allele are at increased risk of having a more severe disease course requiring major surgery, hospitalization, and high-dose systemic corticosteroids within 3 years of diagnosis, according to a Danish study.
Severe UC was defined as having at least one major UC-related operation, at least two UC-related hospitalizations exceeding 2 days, and/or use of at least 5000 mg of systemic corticosteroids within 3 years of diagnosis. Patients not meeting these criteria were considered to have less severe UC and included as the comparison group.Researchers analyzed 4491 patients with UC and determined that carriers of the HLA-DRB1*01:03 allele had a significantly higher risk for severe UC .
Compared with noncarriers, those with this allele had an approximately sixfold increased risk of needing major surgery, a fivefold increased risk of requiring at least two hospitalizations, and a twofold increased risk for use of over 5000 mg of systemic corticosteroids within 3 years of diagnosis. Time-to-event analysis showed that the association between carriers and disease severity extended beyond 3 years after diagnosis.
Compared with noncarriers, those with the HLA-DRB1*01:03 allele had a higher hazard ratio for time to hospitalization, major surgery, and first treatment with systemic corticosteroids.“Although HLA-DRB1*01:03 is a low-frequency allele, carriers have a significantly higher risk of severe ulcerative colitis. Given the low cost of typing a single HLA allele, HLA-DRB1*01:03 could be a valuable tool for risk assessment of patients with ulcerative colitis at diagnosis,” the authors concluded.
Ulcerative Colitis (UC) UC - Ulcerative Colitis Inflammatory Bowel Disease IBD - Inflammatory Bowel Disease IBD Colitis Corticosteroid Genetics Surgery Genomics Genomic Medicine Blood Europe European Human Leukocyte Antigen HLA - Human Leukocyte Antigen Antigens Biomarker Biological Marker Multi-Biomarker Disease Activity MBDA Multibiomarker Disease Activity
United States Latest News, United States Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Antipsychotics Tied to Severe Respiratory Infection RiskThe use of antipsychotics for schizophrenia was associated with higher risk for severe cases of COVID-19 and non–COVID-19 respiratory infections but not mild infection.
Read more »
Researchers identify signs tied to more severe cases of RSVClinician-scientists analyzed samples from patients' airways and blood, finding distinct changes in children with severe cases of RSV, including an increase in the number of natural killer (NK) cells in their airways.
Read more »
Ancient DNA helps uncover the Iberian lynx's potential secret weapon against extinctionMany large mammals have lost genetic diversity, often thanks to the actions of people shrinking their populations. The implications can be severe because without genetic diversity, a population does not have a 'genetic database' to fall back on to adapt to environmental change.
Read more »
Residents Not Evacuating Hurricane Helene Told to ID Selves with MarkerThe Category 4 storm is expected to make landfall in northwestern Florida sometime Thursday night.
Read more »
A possible marker for the risk of developing long COVID.The risk of COVID might have lessened, but long COVID remains a worry for many people. Researchers are looking for risk factors for long COVID, and depression may just be one.
Read more »
Anantara The Marker: Dublin’s Best Kept Secret for Luxury EscapesAnantara The Marker's striking architecture, local cuisine, and indulgent spa, make it one of Ireland’s top luxury destinations.
Read more »