The use of antipsychotics for schizophrenia was associated with higher risk for severe cases of COVID-19 and non–COVID-19 respiratory infections but not mild infection.
Antipsychotic use for schizophrenia or other psychotic disorders is associated with increased risk for severe COVID-19 or other respiratory infection and related hospitalization, a new retrospective study suggests. However, there was no link between antipsychotic use and mild infection outcomes. Researchers analyzed data from several Danish registries on 85,083 individuals with a schizophrenia spectrum disorder, 30,984 of whom were exposed to antipsychotics between 2020 and 2021.
Antipsychotics in the study included clozapine, olanzapine, aripiprazole, quetiapine, risperidone, and zuclopenthixol.Exposure to any antipsychotic was associated with a reduced risk for a positive SARS-CoV-2 test but a significantly increased risk for COVID-related hospitalization . The risks for other respiratory infection-related hospitalization and death were also higher with antipsychotic use.
Antipsychotics Neuroleptics Neuroleptic Drugs COVID-19 2019 Novel Coronavirus 2019-Ncov Wuhan Coronavirus Human Coronavirus HKU1 Human Coronavirus OC43 Hcov-OC43 Human Coronavirus 229E Hcov-229E Corona Virus Covid19 Novel Coronavirus SARS-Cov-2 Respiratory Infections Immunizations Vaccination Treatment Guidelines
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