Frailty emerged as an independent risk factor for severe infection and end-stage renal disease or death across different age groups in older adults with ANCA-associated vasculitis.
Older adults with antineutrophil cytoplasmic antibody –associated vasculitis face a higher risk for end-stage renal disease or mortality and severe infections. However, frailty, more than age, predicts severe infections within 2 years of diagnosis.Researchers conducted a retrospective cohort study using data from the Mass General Brigham ANCA-associated vasculitis cohort in the United States.
Baseline frailty was measured using a claims-based frailty index, with data collected in the year before treatment initiation; individuals were categorized as those who were nonfrail, prefrail, mildly frail, and moderately to severely frail. The outcomes of interest were the incidences of end-stage renal disease or death and severe infections within 2 years of diagnosis. The association of age and frailty with clinical outcomes was assessed in those aged 65-74 years and ≥ 75 years.Frailty was a significant predictor of severe infections within 2 years of ANCA-associated vasculitis diagnosis , showing a stronger association than seen for chronological age ≥ 75 years .
Older age was associated with an increased risk for end-stage renal disease or death ; however, frailty was not.
Vasculitides Angiitis Frailty Frailty Syndrome End Stage Renal Disease ESRD - End Stage Renal Disease ESRD ESKD End-Stage Kidney Disease (ESKD) ESKD - End Stage Kidney Disease Renal Disease Kidney Disease Kidney Disorder Renal Disorder Nephropathy Geriatrics Elder Care Geriatric Medicine Older Adults Seniors Senior Citizens Elderly Healthcare And Medical Technology
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