A data-driven analysis of a large cohort of patients with ANCA-associated vasculitis subclassified the condition into five distinct clusters, offering more accurate survival predictions.
A data-driven subclassification of antineutrophil cytoplasmic antibody –associated vasculitis has identified five distinct clusters with varying degrees of kidney involvement and systemic inflammation, offering insights into improved patient stratification and treatment approaches.ANCA-associated vasculitis is a rare and complex autoimmune disease that is traditionally classified into granulomatosis with polyangiitis and microscopic polyangiitis .
They included 3868 patients diagnosed with ANCA-associated vasculitis between November 1, 1966, and March 1, 2023 , across six European vasculitis registries; while a majority of patients were diagnosed with GPA, the remaining 37.1% were diagnosed with MPA. The clusters with significant kidney involvement were associated with poorer outcomes, including a higher risk for kidney failure and death. The severe kidney cluster had the poorest prognosis, with mortality and the rate of end-stage kidney failure being 30.5% and 41.6%, respectively.
Vasculitides Angiitis Kidneys Chronic Renal Failure Chronic Kidney Failure CKD - Chronic Kidney Disease Chronic Kidney Disease CKD Renal Disease Kidney Disease Kidney Disorder Renal Disorder Nephropathy Renal Failure Renal Insufficiency Kidney Insufficiency Kidney Failure Renal Impairment Artificial Intelligence Deep Learning AI NPL Machine Learning
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