For patients with atrial fibrillation who need protection from stroke and other complications after ablation, left atrial appendage closure rivaled oral anticoagulation in a randomized trial.
A left atrial appendage closure device provides long-term thromboembolic protection that is equivalent to direct oral anticoagulants after ablation forafter ablation for AF, LAA closure should now be considered"an effective first-line option," said Oussama M. Wazni, MD, head of the electrophysiology section at the Cleveland Clinic.
Baseline characteristics in the two groups were comparable. Average age was around 69 years, and about one-third of the patients were women. About 10% of the patients had experienced a previous stroke orIndividual events in the primary composite efficacy endpoint were similar; no differences approached statistical significance. For the mortality endpoint, for example, rates of all-cause death .
The concomitant approach"has the potential to reduce procedural risks and recovery times for patients," he said."In one procedure, we have the potential to decrease AF burden and decrease the risk of stroke and bleeding." LAA closure with the device used in the OPTION study is a"reasonable option" to discuss with patients, said Patel, but he emphasized that the risk for stroke should be sufficient to warrant a prophylactic strategy. The OPTION trial was designed to evaluate LAA closure for the risk for stroke after patients had undergone ablation, not for the primary
AF Afib A-Fib Afib Afib Atrial Fib Atrial Fibrillation (AF) Atrial Fibrillation (A-Fib) AF - Atrial Fibrillation Anticoagulation Therapy Anticoagulant Anticoagulation Thromboembolism Stroke Cerebrovascular Accident CVA - Cerebrovascular Accident Ablation Heart Failure Embolism Heart Closure Device Arteriotomy Closure Device
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