Research has provided compelling evidence that could solve a fundamental mystery in the makeup of fibrils that play a role in Alzheimer's, Parkinson's and other neurodegenerative diseases.
Research has provided compelling evidence that could solve a fundamental mystery in the makeup of fibrils that play a role in Alzheimer's, Parkinson's and other neurodegenerative diseases.
The Food and Drug Administration has approved three new drugs for Alzheimer's disease since 2021, but that was preceded by a 17-year stretch without any new approvals despite hundreds of clinical trials . In 2020, an international team led by researchers in Cambridge using cryo-EM discovered a mysterious mass inside fibrils that were recovered from patients with a neurodegenerative disease called multiple system atrophy.
For example, her team showed that polyphosphate helps stabilize fibrils and reduces their destructive potential against lab cultured neurons. Other researchers have shown that the amount of polyphosphate in rat brains decreases with age. But scientists did have precise, 3D structures of real fibrils from humans thanks to earlier research. By creating computer models of those structures, Jakob and her team could run simulations that asked how polyphosphate would interact with a fibril. They found that it fit the mystery density very well.
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