New details have emerged into how Alzheimer’s disease affects the brain. Researchers have identified cellular changes in the brains of people with the disease — and a timeline of when they occur.
New details have emerged about how Alzheimer’s disease affects the brain. Researchers led by the Allen Institute for Brain Science in Seattle and University of Washington Medicine have identified cellular changes in the brains of people with the disease — and a timeline of when they occur. 'Instead of looking at AD just through the usual lens of plaques and tangles, we focused on how specific cell types were changed in each phase,' study author Dr. Kyle Travaglini, Ph.D.
We identified two main phases in AD by arranging donors along a continuous disease trajectory — a slow, early phase with low levels of pathology and no cognitive decline, followed by a later phase where there’s a huge buildup of pathology and cognitive decline.' The study, which was published this week in Nature Neuroscience, examined millions of cells from the donated brain tissue of 84 deceased Alzheimer’s patients.
Travaglini described that as a 'critical discovery,' as those neurons act as 'brakes' for brain activity and 'keep things balanced.' 'This specificity gives us new clues about how and why certain brain circuits could break down in AD,' he said. Richard J.
The ability to detect these early changes means that, for the first time, we can see what is happening to a person’s brain during the earliest periods of the disease,' he said in the release. 'For the first time, we can see what is happening to a person’s brain during the earliest periods of the disease.
If the findings in this new paper are confirmed by other labs, it raises the question of whether effectively addressing the brain changes that happen in what the authors call the first ‘quiet’ phase can slow, delay or prevent the second, more destructive phase.' Looking ahead, Fontana says it will be important to further investigate the 'quiet' phase to confirm how it’s linked to the better-known biomarkers of Alzheimer’s, such as amyloid and tau. For more Health articles, visit www.
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