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Research on MDMA’s use in psychotherapy have led to new variants developed by MedUni Vienna that could offer similar benefits with reduced side effects, paving the way for safer, controlled therapeutic applications.The global conversation around using 3,4-methylenedioxy-N-methylamphetamine , popularly known as “ecstasy,” in psychotherapy for mental illnesses like post-traumatic stress disorder is gaining momentum.
An international research team led by MedUni Vienna has now identified three new variants of MDMA as promising alternatives for safer use in a controlled psychotherapeutic setting as part of a study. The results were recently published in theThe currently developed MDMA variants have been modified by the researchers in such a way that the positive effects are retained and the negative effects are reduced.
The MDMA analogs currently identified may provide promising alternatives: “Our experimental results showed that the new variants can retain the therapeutic potential of the conventional substance, but are likely to cause fewer side effects.” Harald Sitte summarizes the significance of the results: “This could advance the controlled use of psychoactive substances in neuropsychiatric illness.
Reference: “Bioisosteric analogs of MDMA: Improving the pharmacological profile?” by Ana Sofia Alberto-Silva, Selina Hemmer, Hailey A. Bock, Leticia Alves da Silva, Kenneth R. Scott, Nina Kastner, Manan Bhatt, Marco Niello, Kathrin Jäntsch, Oliver Kudlacek, Elena Bossi, Thomas Stockner, Markus R. Meyer, John D. McCorvy, Simon D. Brandt, Pierce Kavanagh and Harald H. Sitte, 19 June 2024,SciTechDaily: Home of the best science and technology news since 1998.
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