Small trial of Bemdaneprocel, which aims to replace dopamine-producing neurons, raises hope for treatment
Scientists have reported early success in a trial of an experimental cell therapy for Parkinson’s disease, raising hope for patients.
“The data from this phase 1 open label study are extremely encouraging,” said Claire Henchcliffe, a neurologist at the University of California, Irvine, who was one of the study’s principal investigators. “While this is a small open label study, meeting the study’s primary objective for safety and tolerability along with initial improvements seen in clinical outcomes represents a great step forward.
Bemdaneprocel involves an injection into the brain of dopamine-producing neurons grown from human embryonic stem cells in the lab. The hope is that these replacement cells will integrate with existing brain circuits and reverse the effects of the disease. Claire Bale, an associate director of research at Parkinson’s UK, said: “It’s great news, particularly that they’re able to crack on with phase 2 so quickly, and it’s great seeing the brain scans looking like the grafts are surviving.”
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