Our Duke vs. LSU predictions, odds & expert picks are calling for a tightly-contested battle in Sacramento on March 27, 2026.
A gut-punch regular-season loss in December has the Duke Blue Devils ready to strike back, keeping the LSU Lady Tigers on alert in this Sweet 16 showdown.Photo By - Reuters Connect.LSU's Flau'jae Johnson celebrates a three point shot during second round action of the NCAA Women's March Madness Tournament.
There’s nothing quite like revenge, especially in the Sweet 16. The Duke Blue Devils haven’t forgotten their 93-77 loss to the LSU Lady Tigers in December, a defeat that stung deeply. Since then, Duke has had time to regroup, make adjustments, and study how LSU executes its game plan. This sets the stage for a highly competitive matchup, with the Blue Devils ready to make tonight’s clash a closely contested battle.The Lady Tigers have been strong in the paint, both scoring and rebounding. With standout post players controlling the boards, LSU can limit Duke’s second-chance points while generating extra opportunities for themselves. This physicality inside may force Duke to rely on perimeter shooting, which can be streaky.Duke’s biggest test will be keeping LSU’s bigs, Kate Koval and Amiya Joyner, in check. To do that, the Blue Devils will rely on Toby Fournier and Delaney Thomas. In the NCAA Tournament so far, LSU has outscored opponents 112-34 in points in the paint, while Duke sits at 80-44, highlighting the battle that will define this matchup. Since their last meeting, Duke has tightened up defensively, holding opponents to just 55.7 points per game. As the team’s leading scorer , top rebounder , and primary shot-blocker , Fournier must stay aggressive in limiting LSU’s interior presence. Meanwhile, Thomas — who powered Duke past Baylor in the second round with a 17-point performance — will need to continue producing key points and energy inside to help the Blue Devils stay competitive. It’s simple: Duke keeps the Tigers out of the paint and maintain the lockdown defense they’ve become known for, they’ll stay within striking distance and keep LSU on their heels.Duke hasn’t defeated the LSU Lady Tigers in the Women’s NCAA Tournament since their tightly contested second-round clash in 2010, when the Blue Devils edged out a 60-52 win over the purple and gold.As previously mentioned, Duke’s defense has improved dramatically since December, particularly in creating turnovers that can fuel their offense on the other end. While LSU also prides itself on stout defensive play, both teams are too deep and talented for this game to trend Under. The Lady Tigers lead the nation in bench scoring and overall offense , while Duke is 10-3 when hitting 35% or better from three-point range, with a +18 average margin of victory. With elite rosters on both sides, the pace and talent should push this game to the Over, even with strong defense in play at Golden 1 Center. Ultimately, LSU looks more than ready to secure a fourth consecutive Elite Eight appearance. Duke will challenge them every step of the way, but the Lady Tigers’ depth and balance make them the team likely to come out on top.Duke is 10-3 with a +18 margin of victory when it shoots at or over 35% from beyond the arc: Our team of experts has thoroughly researched and handpicked each product that appears on our website. We may receive compensation if you sign up through our links. Hailing from Harlem, New York, Aisha Quiñones joined Covers in 2024 after an illustrious career with several other major media outlets. A proud Johnnie, after graduating from the Big East basketball powerhouse St. John's University, Quiñones earned her bachelor's degree in sport management and journalism, then obtained her master's degree in media studies from The New School. Over a span of 12+ years, Quiñones has built her portfolio as a writer, dipped her toe into on-camera work, and also been behind the scenes in producing sports content. Despite being a New Yorker, Quiñones has always been a lifelong Los Angeles Lakers fan thanks to her mom's joy of watching Kobe Bryant play — so much of a fan to the point that Quiñones named her toy poodle after the late-great legend. Her hometown roots stay true to her MLB and WNBA choice in teams, as a Yankees and Liberty fan, due to her uncle and grandmother's love for the sports throughout her childhood.March Madness Expert Picks: Daily Best Bets and PredictionsTennessee vs Iowa State Prediction, Picks & Best Bets for Tonight's March Madness GameCopyright © 1995 - 2026 CS Media Limited All Rights Reserved. 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