Patients with recurrent or metastatic head and neck squamous cell carcinoma can discontinue immune checkpoint inhibitors at 1 or 2 years without negatively impacting survival, a study suggests.
Patients with recurrent or metastatic head and neck squamous cell carcinoma treated with immune checkpoint inhibitors show comparable survival outcomes whether they continued or discontinued treatment at 1 or 2 years vs continued past those points.Although ICIs are a frontline treatment for patients with recurrent or metastatic HNSCC, questions remain about the optimal duration of therapy, and the advantages and risks of reintroducing ICIs after disease progression.
The study compared outcomes of patients who discontinued ICI therapy at 1 and 2 years vs those who continued beyond those two points, and assessed outcomes after ICI rechallenge. The immediate rechallenge group restarted ICI treatment after a break of at least 60 days without any non-ICI therapy. The delayed rechallenge group had a non-ICI therapy between their initial and subsequent ICI treatments.
HPV - Human Papillomavirus Human Papillomavirus HPV Squamous Carcinoma Squamous Cancer Squamous Cell Carcinoma Cancer Malignant Neoplasia Carcinoma Malignant Neoplasm Healthcare And Medical Technology Health And Medical Tech Health And Med Tech Health And Medical Technology Healthcare Technology Medical Technology
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