In an adjuvant setting, the combination lowered the risk for death among patients with resected stage III melanoma but that benefit failed to reach statistical significance.
reduces the risk for death by 20% compared with placebo, though the overall survival benefit does not reach statistical significance. The combination lowers the risk for death by a greater degree — 25% — in patients with aInterim results from the phase 3 COMBI-AD trial found that the combination improved recurrence-free survival in this patient population compared with placebo.
In the final analysis of the COMBI-AD trial, researchers assessed overall survival and other survival metrics after more than 8 years of follow-up.V600 mutations to 150 mg twice daily dabrafenib plus 2 mg once daily trametinib or placebo for 12 months.At 8 years, 71% of the patients who received dabrafenib plus trametinib survived vs 65% of those who received placebo, suggesting a 20% lower risk for death in the combination group .
Overall, 97% of the patients in the combination group experienced an adverse event vs 88% in the placebo group. Serious adverse events occurred in 41% of the combination group vs 13% of the placebo group. The incidence of primary or secondary cancer was higher in the combination group as well — 3.98 events per 100 patient-years vs 2.61 in the placebo group.
Malignant Melanoma Skin Cancer Malignant Skin Neoplasm BRAF Adjuvant Setting Adjuvant Therapy Metastasis Metastatic Carcinoma Metastatic Cancer Metastases Distant Metastasis Distant Metastases Cancer Malignant Neoplasia Carcinoma Malignant Neoplasm
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