As we age, our muscles atrophy. Earlier this year, researchers found that hepatocyte growth factor (HGF), a protein critical in skeletal muscle development loses its functionality due to nitration as we age.
As we age, our muscles atrophy. Earlier this year, researchers found that hepatocyte growth factor , a protein critical in skeletal muscle development loses its functionality due to nitration as we age. Now, the same team has developed a monoclonal antibody that blocks the nitration sites of HGF, effectively preventing the protein's age induced loss of function. Their findings were validated utilizing rat muscles cell culture.
"Earlier this year, our team found out that HGF undergoes a process called nitration. This is when a molecule of nitrogen dioxide attaches to the amino acid tyrosine on the protein," explains Professor Ryuichi Tatsumi of the Faculty of Agriculture who led the study."This is a common modification we see in biology. However, we found that HGF loses its physiological activity when it becomes nitrated, and this phenomenon accumulates with age.
Through further testing the team found that the new antibodies did not disrupt HGF activity itself, meaning it could still activate satellite cells. In vitro immuno‐prevention of nitration/dysfunction of myogenic stem cell activator HGF, towards developing a strategy for age‐related muscle atrophyProteins are essential for body growth and muscle building. However, protein metabolism varies depending on the body's internal biological clock. Therefore, it is important to know how ...
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