Scientists used the gene-editing technology to treat people with cancer in a new study
, scientists recruited 16 people who had already received standard treatment for their cancer but whose cancers had returned. They wanted to use the gene-editing therapy in a new way and infuse patients with an army of immune cells that had been genetically modified to specifically fight their individual cancers.
While previous CRISPR-based strategies for cancer have involved removing genes in cancer cells that help them grow, or that prevent the immune system from recognizing and attacking malignant cells, this approach introduces specific cancer-fighting immune cells that ultimately will help the patient avoid recurrences as well.
“The CRISPR editing approach worked really well, and the guides we used cut the genome in just one place, where we removed the gene and inserted the other gene,” says Ribas. The study was done in a couple of patients first, at a low dose [of the edited cells that were infused], and the team worked up to a higher dose once the therapy appeared safe.
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