[ICYMI] COVID-19 | Why an Israeli company is developing an oral vaccine
File: A nurse prepares a dose of the Moderna vaccine against Covid-19, during the vaccination day called"Vacunaton", which takes place in the National Stadium, and where the aim is to immunise 50,000 Hondurans over 35 years of age against the coronavirus during the weekend, in Tegucigalpa, on July 31, 2021.WASHINGTON - Imagine a Covid-19 vaccine that came as a pill: no needles, no medical professionals required to administer it, potentially delivered directly to people's homes.
Oral vaccines are particularly attractive for the developing world, because they reduce the logistical burden of immunization campaigns, said Kidron. "In order for the vaccine to really work well, we need as many people to take it as possible," said Kidron.- Challenges for oral delivery - Oramed, which was founded in 2006, believes it has overcome the technical hurdles by designing a capsule that survives the highly acidic environment of the gut.
It also releases molecules called protease inhibitors that stop enzymes in the small intestine from breaking down the insulin, and an absorption enhancer to help the insulin cross into the bloodstream. These mimic three key structures of the pathogen: the spike protein, the envelope protein and the membrane protein.
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