Individuals at a high genetic risk for gout faced a significantly higher risk for cardiovascular disease than those at a lower genetic risk and would benefit from adhering to a healthy lifestyle.
Genetic predisposition to gout, unfavorable lifestyle habits, and poor metabolic health are associated with an increased risk for cardiovascular disease ; however, adherence to a healthy lifestyle can reduce this risk by up to 62%, even in individuals with high genetic risk.Researchers investigated the association between genetic predisposition to gout, combined with lifestyle habits, and the risk for CVD in two diverse prospective cohorts from different ancestral backgrounds.
They analyzed the data of 224,689 participants of European descent from the UK Biobank and 50,364 participants of East Asian descent from the Korean Genome and Epidemiology Study . The genetic predisposition to gout was evaluated using a polygenic risk score derived from a metagenome-wide association study, and the participants were categorized into low, intermediate, and high genetic risk groups based on their PRS for gout.
A favorable lifestyle was defined as having ≥ 3 healthy lifestyle factors, and 0-1 metabolic syndrome factor defined the ideal metabolic health status.Individuals in the high genetic risk group had a higher risk for CVD than those in the low genetic risk group in both the UK Biobank (adjusted hazard ratio , 1.10;In the UK Biobank cohort, individuals with a high genetic risk for gout and unfavorable lifestyle choices had a 1.
This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.Best Practice Treatment and Management of Patients with Type 2 Diabetes, Cardiovascular Disease, and Heart Failure
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