Achieving weight loss within a year of initiating orlistat can reduce the risk for both incident gout and recurrent gout flares in patients with overweight or obesity.
A higher rate of weight loss within 1 year of initiating orlistat is associated with lower risks for incident gout and recurrent gout flares in individuals with body mass index > 25, particularly if they have obesity or high baseline serum urate levels.
The risk for recurrent gout flares was evaluated in 3847 individuals with overweight or obesity , who had gout before initiating orlistat. The primary outcome was incident gout, and the secondary outcome was the rate of recurrent gout flares during the 5-year follow-up period after initiating orlistat.The 5-year risk for incident gout was the lowest among patients in the fast weight loss group and highest among those in the weight gain or stable weight group .
Similarly, faster weight loss rates were linked to lower rates of recurrent gout flares, with risk ratios of 0.71 and 0.83 in the fast and moderate weight loss groups, respectively.
Weight Loss Obesity Obese Weight Management Body Mass Index BMI Weight Gain Arthritis Joint Inflammation Artificial Intelligence Deep Learning AI NPL Machine Learning ML Natural Language Processing Artificial Neural Networks Clinical Research Clinical Trials Clinical Studies Pre-Clinical Trial Double-Blind Study Double-Blind Studies Single-Blind Study Single-Blind Studies
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