Exposing mice with various different types of cancer to 4°C activated their brown fat tissue, prompting it to burn glucose, which tumours rely on for growth
at the Karolinska Institute in Sweden and his colleagues implanted five different types of cancerous cells into a group of mice. Some of the rodents were then continuously exposed to very low temperatures, but above 0°C, for 20 days., which burns energy rather than storing it, reducing the tumours’ energy supply.
“This is really something new: not directly targeting cancer cells, but rather altering global metabolism in the body to affect tumours,” says Cao. The inhibition was also absent when the mice were fed a high-glucose diet, suggesting that the tumours’ growth was inhibited by a lack of glucose. The team also performed a genetic analysis on the cold-exposed tumours, finding a decrease in markers associated with glucose consumption.In a second part of the experiment, Cao and his team exposed a group of six healthy human volunteers to 16°C for 2 to 6 hours a day for two weeks.
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